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Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.

Authors
  • Gautret, Philippe1
  • Lagier, Jean-Christophe2
  • Parola, Philippe1
  • Hoang, Van Thuan3
  • Meddeb, Line4
  • Mailhe, Morgane4
  • Doudier, Barbara4
  • Courjon, Johan5
  • Giordanengo, Valérie6
  • Vieira, Vera Esteves4
  • Dupont, Hervé Tissot2
  • Honoré, Stéphane7
  • Colson, Philippe2
  • Chabrière, Eric2
  • La Scola, Bernard2
  • Rolain, Jean-Marc2
  • Brouqui, Philippe2
  • Raoult, Didier8
Type
Published Article
Journal
International journal of antimicrobial agents
Publication Date
Mar 20, 2020
Pages
105949–105949
Identifiers
DOI: 10.1016/j.ijantimicag.2020.105949
PMID: 32205204
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the role of hydroxychloroquine on respiratory viral loads. French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16th, to receive 600mg of hydroxychloroquine daily and their viral load in nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical presentation, azithromycin was added to the treatment. Untreated patients from another center and cases refusing the protocol were included as negative controls. Presence and absence of virus at Day6-post inclusion was considered the end point. Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms. Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration than reported of untreated patients in the literature. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination. Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin. Copyright © 2020. Published by Elsevier B.V.

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