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Hydroxamate-based inhibitors of low affinity IgE receptor (CD23) processing.

Authors
  • Bailey, S
  • Bolognese, B
  • Buckle, D R
  • Faller, A
  • Jackson, S
  • Louis-Flamberg, P
  • McCord, M
  • Mayer, R J
  • Marshall, L A
  • Smith, D G
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jan 06, 1998
Volume
8
Issue
1
Pages
23–28
Identifiers
PMID: 9871622
Source
Medline
License
Unknown

Abstract

A series of hydroxamic acids related to the non-selective matrix metalloprotease inhibitor Batimastat is described, which inhibits the proteolytic cleavage of the low affinity IgE receptor from cell membrane preparations. Limited SAR studies suggest that the structural requirements for effective inhibition are distinct from those required for the inhibition of collagenase.

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