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Hydrophobic organic solvents activate human platelets in vitro.

Authors
  • Kyvik, K R
  • Aarbakke, G M
  • Klausen, H
  • Holmsen, H
  • Tysnes, O B
Type
Published Article
Journal
Platelets
Publication Date
Jan 01, 1994
Volume
5
Issue
4
Pages
193–200
Identifiers
DOI: 10.3109/09537109409006046
PMID: 21043719
Source
Medline
License
Unknown

Abstract

The purpose of this study was to investigate blood platelet function during exposure to the hydrophobic organic solvents toluene, p-xylene and n-hexane. Human blood platelets were exposed for 30 min at 37°C to a saturated atmosphere of p-xylene, toluene or n-hexane. All three solvents, and the aromatics in particular, induced a decrease in the number of single platelets (61-88%) together with an increase in the extracellular levels of ATP plus ADP (45-65% of total) and serotonin (67-100% of total). Passive leakage of [(14)C] adenine-labelled nucleotides from the metabolic pool, due to platelet lysis, was minor or delayed. Electron microscopy of platelets exposed to p-xylene revealed aggregation. The platelets were spherical without pseudopods. Our results indicate that the hydrophobic solvents n-hexane, p-xylene and toluene induce platelet aggregation and dense granule secretion.

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