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Hydrogen Sulfide as Potential Regulatory Gasotransmitter in Arthritic Diseases

Authors
  • Sunzini, Flavia
  • De Stefano, Susanna
  • Chimenti, Maria Sole
  • Melino, Sonia
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
Feb 11, 2020
Volume
21
Issue
4
Identifiers
DOI: 10.3390/ijms21041180
PMID: 32053981
PMCID: PMC7072783
Source
PubMed Central
Keywords
License
Green

Abstract

The social and economic impact of chronic inflammatory diseases, such as arthritis, explains the growing interest of the research in this field. The antioxidant and anti-inflammatory properties of the endogenous gasotransmitter hydrogen sulfide (H2S) were recently demonstrated in the context of different inflammatory diseases. In particular, H2S is able to suppress the production of pro-inflammatory mediations by lymphocytes and innate immunity cells. Considering these biological effects of H2S, a potential role in the treatment of inflammatory arthritis, such as rheumatoid arthritis (RA), can be postulated. However, despite the growing interest in H2S, more evidence is needed to understand the pathophysiology and the potential of H2S as a therapeutic agent. Within this review, we provide an overview on H2S biological effects, on its role in immune-mediated inflammatory diseases, on H2S releasing drugs, and on systems of tissue repair and regeneration that are currently under investigation for potential therapeutic applications in arthritic diseases.

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