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Hydrogen peroxide neurotoxicity in childhood: case report with unique magnetic resonance imaging features.

Authors
  • Cannon, George
  • Caravati, E Martin
  • Filloux, Francis M
Type
Published Article
Journal
Journal of Child Neurology
Publisher
SAGE Publications
Publication Date
Nov 01, 2003
Volume
18
Issue
11
Pages
805–808
Identifiers
PMID: 14696912
Source
Medline
License
Unknown

Abstract

Concentrated hydrogen peroxide (H2O2) intoxication is relatively rare in children. Serious irreversible neurotoxicity generally results. The case of an 11-year-old boy who inadvertently drank a concentrated (35%) H2O2 solution is described. He exhibited signs of an acute encephalopathy with cortical visual impairment. Extensive cerebrocortical diffusion restriction with apparent gyral edema was evident at 3 days following ingestion, particularly in the parieto-occipital regions bilaterally. Spontaneous neurologic improvement quickly followed, and nearly full clinical resolution was evident 1 month later. The pattern of imaging abnormalities closely resembles that of reversible posterior leukoencephalopathy. Concentrated H2O2 neurotoxicity in children can exhibit unique patterns (a reversible posterior leukoencephalopathy) and a better than expected outcome.

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