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Hydrogen peroxide-dependent arteriolar dilation in contracting muscle of rats fed normal and high salt diets.

Authors
  • Marvar, Paul J
  • Hammer, Leah W
  • Boegehold, Matthew A
Type
Published Article
Journal
Microcirculation (New York, N.Y. : 1994)
Publication Date
Jan 01, 2007
Volume
14
Issue
8
Pages
779–791
Identifiers
PMID: 17934963
Source
Medline
License
Unknown

Abstract

These results indicate that locally produced H2O2 contributes to arteriolar dilation and hyperemia in contracting skeletal muscle, and that the effect of H2O2 on arteriolar tone in this vascular bed is mediated largely through K+ channel activation. High dietary salt intake does not reduce the contribution of H2O2 to active hyperemia, or alter the mechanism through which H2O2 relaxes arteriolar smooth muscle.

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