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Hydro-Ethanolic Fruit Extract of Capsicum frutescens Reversed Triton-X-100-Induced Hyperlipidaemia in Rats.

Authors
  • Adigun, Nurudeen S1
  • Oladiji, A Temidayo1
  • Ajiboye, Taofeek O2
  • 1 Department of Biochemistry, University of Ilorin, Ilorin, Nigeria. , (Niger)
  • 2 Antioxidants Redox Biology and Toxicology Research Group, Department of Medical Biochemistry College of Health Sciences, Nile University of Nigeria, FCT-Abuja, Nigeria. , (Niger)
Type
Published Article
Journal
Journal of dietary supplements
Publication Date
Jan 01, 2020
Volume
17
Issue
1
Pages
53–66
Identifiers
DOI: 10.1080/19390211.2018.1482982
PMID: 30451048
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This study evaluates the anti-hyperlipidaemic and antioxidant activities of hydro-ethanolic fruits extract of Capsicum frutescens in hyperlipidemia rats. The secondary volatile metabolite constituents of the extract were identified using Gas chromatography. In vitro antioxidant activity of the extract (0.2-1.0 mg/mL) was investigated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical, hydrogen peroxide (H2O2) and hydroxyl radical (OH.). In vivo antioxidant and anti-hyperlipidaemic properties of the extract were evaluated in triton X-100-induced hyperlipidaemic rats. Gas chromatogram indicates the presence of 13 compounds with tans β-ocimene being the major constituent. The extract scavenged DPPH, H2O2 and OH. radicals in concentrations dependent manner. C. frutescens reversed triton X-100-mediated increase in serum total cholesterol, triglycerides and low-density lipoprotein, and reduction in high-density lipoprotein. Triton X-100-mediated decrease in superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phospahte dehydrogenase were significantly reversed by the extract. The results indicate that C. frutescens has antioxidant and anti-hyperlipidaemic properties.

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