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Hydroalcoholic extract of Caryocar brasiliense Cambess. leaves affect the development of Aedes aegypti mosquitoes

Authors
  • Morais, Hevilem Letícia Moura do Nascime...1
  • Feitosa, Talita Carneiro2
  • Rodrigues, João Gustavo Mendes3
  • Lira, Maria Gabriela Sampaio4
  • Nogueira, Ranielly Araújo4
  • Luz, Tássio Rômulo Silva Araújo5
  • Silva-Souza, Nêuton2
  • Lima, Nerilson Marques6
  • Andrade, Teresinha de Jesus Aguiar dos S...1
  • Miranda, Guilherme Silva1, 3
  • 1 Instituto Federal de Educação, Ciência e Tecnologia do Maranhão, Departamento de Educação, São Raimundo das Mangabeiras, MA, Brasil.
  • 2 Universidade Estadual do Maranhão, Departamento de Química e Biologia, São Luís, MA, Brasil.
  • 3 Universidade Federal de Minas Gerais, Departamento de Parasitologia, Belo Horizonte, MG, Brasil.
  • 4 Universidade Federal do Maranhão, Departamento de Patologia, São Luís, MA, Brasil.
  • 5 Universidade Federal do Maranhão, Departamento de Farmácia, São Luís, MA, Brasil.
  • 6 Universidade Federal de Juiz de Fora, Departamento de Química, Juiz de Fora, MG, Brasil.
Type
Published Article
Journal
Revista da Sociedade Brasileira de Medicina Tropical
Publisher
Sociedade Brasileira de Medicina Tropical - SBMT
Publication Date
Sep 11, 2020
Volume
53
Identifiers
DOI: 10.1590/0037-8682-0176-2020
PMID: 32935784
PMCID: PMC7491563
Source
PubMed Central
Keywords
License
Green

Abstract

INTRODUCTION: Curtailing the development of the aquatic immature stages of Aedes aegypti is one of the main measures to limit their spread and the diseases transmitted by them. The use of plant extracts is a promising approach in the development of natural insecticides. Thus, this research aimed to characterize the inhibitory effect of the hydroalcoholic extract of Caryocar brasiliense leaves on the emergence of adult A. aegypti and the main substances that constitute this extract. METHODS: C. brasiliense leaf extract was prepared by ethanol (70%) extraction. Bioassays using L3 larvae were performed at concentrations of 200, 300, 400, and 500 ppm. We identified the major secondary metabolites present in this extract, and performed toxicity tests on an off-target organism, Danio rerio . RESULTS: We observed a significant delay in the development of A. aegypti larvae mainly at a concentration of 500 ppm, and estimated an emergence inhibition for 50% of the population of 150 ppm. Moreover, the C. brasiliense leaf extracts exhibited low toxicity in D. rerio . The main compounds found in the extract were quercetin, violaxanthin, myricetin3-O-hexoside, methyl-elagic-3-arabinose acid, and isoquercitrin. CONCLUSIONS: Herein, we demonstrate the inhibition of mosquito development by the hydroalcoholic extract of C. brasiliense and suggest substances that may act as active principles.

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