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Hybridizing Simulated Moving Bed and Electrodialysis: Product Purification and Eluent Regeneration.

Authors
  • Kochendoerfer, Kiara1
  • Sa Gomes, Pedro1
  • Rütze, Dennis N2
  • Pathapati, Trinath2
  • de Wit, Pieter2
  • Zaalberg, Menne2
  • 1 BASF SE Carl-Bosch-Strasse 38 67056 Ludwigshafen Germany. , (Germany)
  • 2 Xendo B.V. Bio Science Park, Schipholweg 73-75 2316 ZL Leiden The Netherlands. , (Netherlands)
Type
Published Article
Journal
Chemical engineering & technology
Publication Date
Dec 01, 2018
Volume
41
Issue
12
Pages
2418–2426
Identifiers
DOI: 10.1002/ceat.201800298
PMID: 31007409
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Complex streams in bio-based industries require efficient downstream processing units. Simulated moving-bed (SMB) chromatography is known to improve process efficiency by reducing resin and buffer requirement, but it can be further enhanced by technology hybridization. In the current experiments, an SMB system has been integrated with a bipolar electrodialysis (BPED) system. SMB purified γ-aminobutyric acid (GABA) from a clarified fermentation broth while BPED processed the product-containing eluent stream into recyclable eluent and purified product streams. The continuous operation did not result in any impurity accumulation.

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