Hybridizing Simulated Moving Bed and Electrodialysis: Product Purification and Eluent Regeneration.
BASF SE Carl-Bosch-Strasse 38 67056 Ludwigshafen Germany.
Xendo B.V. Bio Science Park, Schipholweg 73-75 2316 ZL Leiden The Netherlands.
- Published Article
Chemical engineering & technology
- Publication Date
Dec 01, 2018
Complex streams in bio-based industries require efficient downstream processing units. Simulated moving-bed (SMB) chromatography is known to improve process efficiency by reducing resin and buffer requirement, but it can be further enhanced by technology hybridization. In the current experiments, an SMB system has been integrated with a bipolar electrodialysis (BPED) system. SMB purified γ-aminobutyric acid (GABA) from a clarified fermentation broth while BPED processed the product-containing eluent stream into recyclable eluent and purified product streams. The continuous operation did not result in any impurity accumulation.
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This record was last updated on 10/06/2020 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/31007409