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Hybrid of Monkey and Human Adenoviruses

Authors
  • A. D. Altstein
  • N. N. Dodonova
  • N. N. Vassilyeva
  • E. M. Tsetlin
Publication Date
May 01, 1968
Source
PMC
Keywords
Disciplines
  • Design
License
Unknown

Abstract

Following joint replication of monkey SA7 adenovirus (C8 strain) and human adenovirus type 2 in green monkey kidney tissue culture, a virus possessing the properties of a hybrid was obtained. It was designated Ad2C8. Ad2C8 preparations contained two types of viral particles: human adenovirus type 2, and hybrid particles. The hybrid virions multiplied in green monkey kidney cells in the presence of human adenovirus types 1, 2, and 3, but not 3 and 7, and acquired the capsid of the helper adenovirus. The hybrid can serve as a helper for human adenoviruses. It can apparently induce T antigen of the C8 virus but, in contrast to the latter, does not induce tumors in hamsters.

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