Affordable Access

deepdyve-link
Publisher Website

Hybrid Imaging for Patient-Specific Dosimetry in Radionuclide Therapy.

Authors
  • Ljungberg, Michael1
  • Gleisner, Katarina Sjögreen2
  • 1 Department of Medical Radiation Physics, Lund University, 221 85 Lund, Sweden. [email protected] , (Sweden)
  • 2 Department of Medical Radiation Physics, Lund University, 221 85 Lund, Sweden. [email protected] , (Sweden)
Type
Published Article
Journal
Diagnostics
Publisher
MDPI AG
Publication Date
Jul 10, 2015
Volume
5
Issue
3
Pages
296–317
Identifiers
DOI: 10.3390/diagnostics5030296
PMID: 26854156
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Radionuclide therapy aims to treat malignant diseases by systemic administration of radiopharmaceuticals, often using carrier molecules such as peptides and antibodies. The radionuclides used emit electrons or alpha particles as a consequence of radioactive decay, thus leading to local energy deposition. Administration to individual patients can be tailored with regards to the risk of toxicity in normal organs by using absorbed dose planning. The scintillation camera, employed in planar imaging or single-photon emission computed tomography (SPECT), generates images of the spatially and temporally varying activity distribution. Recent commercially available combined SPECT and computed tomography (CT) systems have dramatically increased the possibility of performing accurate dose planning by using the CT information in several steps of the dose-planning calculation chain. This paper discusses the dosimetry chain used for individual absorbed-dose planning and highlights the areas where hybrid imaging makes significant contributions.

Report this publication

Statistics

Seen <100 times