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Hyaluronic Acid Coated Acid-Sensitive Nanoparticles for Targeted Therapy of Adjuvant-Induced Arthritis in Rats

Authors
  • Yu, Changhui
  • Li, Xiangyu
  • Hou, Yufei
  • Meng, Xiangxue
  • Wang, Deli
  • Liu, Jiaxin
  • Sun, Fengying
  • Li, Youxin
Publication Date
Jan 02, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

2.84 mV. The release rate of Dex from HAPNPs/Dex in vitro increased markedly when the pH decreased from 7.4 to 4.5, indicating that the HAPNPs were pH-sensitive. In a cellular uptake study, stronger fluorescence signals were observed in activated macrophages treated with HAPNPs, suggesting that HAPNPs could be effective nanodevices target to activated macrophages. In rats with adjuvant-induced arthritis, HAPNPs could inhibited the progression of RA. Taken together, these results suggest that the HAPNPs could be useful in RA therapy.

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