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Hyaluronate-Peanut Agglutinin Conjugates for Target-Specific Bioimaging of Colon Cancer

Authors
  • Beack, S.
  • Cho, M.
  • Kim, Y.-E.
  • Ahn, G.-O.
  • Hahn, S.K.
Publication Date
Mar 01, 2017
Source
[email protected]
Keywords
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Unknown
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Abstract

Colon cancer is one of the most common death-related cancers in the world. For treating colon cancer, it is crucial to detect and remove malignant lesions early. Here, we developed hyaluronate (HA)-peanut agglutinin (PNA) conjugates for the bioimaging of colon cancer. The HA-PNA conjugates were successfully synthesized by the coupling reaction between aldehyde-modified HA and the N-terminal amine group of PNA. For diagnostic imaging, rhodamine B (RhoB) was chemically conjugated onto PNA in HA-PNA conjugates. After intraluminal injection of HA-PNA-RhoB conjugates into tumor-bearing mice, small-sized colon cancers could be effectively visualized by ex vivo imaging with an in vivo imaging system (IVIS) and a two-photon microscope. With these results taken together, we could confirm the feasibility of HA-PNA-RhoB conjugates as a bioimaging agent for detecting colon cancers. ? 2017 American Chemical Society. / 1

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