Affordable Access

Humoral Immunity Reflects Altered T Helper Cell Bias in Borrelia burgdorferi-Infected γδ T-Cell-Deficient Mice

Authors
  • Linda K. Bockenstedt
  • Marie-Claude Shanafelt
  • Alexia Belperron
  • Jialing Mao
  • Stephen W. Barthold
Publisher
American Society for Microbiology
Publication Date
May 01, 2003
Source
PMC
Keywords
Disciplines
  • Medicine
License
Unknown

Abstract

In murine Lyme borreliosis, the absence of γδ T lymphocytes augments the T helper cell 2 type humoral response but does not alter disease susceptibility. Arthropod transmission of Borrelia burgdorferi spirochetes results in similar antibody isotypes when γδ T cells are present, suggesting that vector effects can negate γδ T-cell functions in vivo.

Report this publication

Statistics

Seen <100 times