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Humoral immune responses in Gambians to Pfs16, an immunodominant, Plasmodium falciparum integral membrane protein.

Authors
  • Baker, D A
  • Drakeley, C J
  • Ong, C S
  • Lulat, A G
  • Greenwood, B M
  • Targett, G A
Type
Published Article
Journal
Parasite immunology
Publication Date
Oct 01, 1996
Volume
18
Issue
10
Pages
527–533
Identifiers
PMID: 9226690
Source
Medline
License
Unknown

Abstract

Naturally acquired humoral immune responses to Pfs16, an integral membrane protein expressed in Plasmodium falciparum gametocytes and sporozoites, were investigated in The Gambia. A high prevalence of antibodies to this molecule was detected by peptide ELISA. Ninety-three per cent of the people taking part in a survey at the end of the rainy season (November) had serum antibodies to one or more synthetic peptides spanning the sequence: 88% reacted with one particular peptide sequence (IMLIILSGIVGFKVK) whereas only one out of ten non-Gambians (taking anti-malarial prophylaxis with no history of infection) reacted with the peptide. Epitope mapping with mouse MoAbs has shown that this peptide is located on a part of the molecule differing from immunodominant regions of the molecule identified in a previous study in Papua New Guinea.

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