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Humoral and cellular immune responses to the GB virus C/hepatitis G virus envelope 2 protein.

Authors
  • Lazdina, U
  • Hultgren, C
  • Chen, M
  • Fischler, B
  • Weiland, O
  • Mushahwar, I K
  • Sällberg, M
Type
Published Article
Journal
Journal of medical virology
Publication Date
Nov 01, 2000
Volume
62
Issue
3
Pages
334–344
Identifiers
PMID: 11055243
Source
Medline
License
Unknown

Abstract

Immune responses to two recombinant envelope 2 (E2) proteins, representing genotypes 1 and 2 of the GB virus C, or the hepatitis G virus (GBV-C/HGV), were studied in mice and in 48 individuals with, or without, chronic, or past GBV-C/HGV infection. Immunised mice developed E2-specific antibodies (mean titres, 1:1,167 to 1:9,360), recognising linear antigenic regions and proliferative and IL-2, IL-6 and gammaIFN cytokine responses regardless of the viral genotype. Individuals with past GBV-C infection had E2 antibody titres from 1:1,500 to 1:7,500 that did not recognise the E. coli derived E2 protein or linear antigenic regions. Proliferative E2-specific responses were detected in peripheral blood mononuclear cells from 6/22 (27%) persons with, and in none without GBV-C markers (P<0.05). Thus, E2-specific immune responses are mainly crossreactive between different variants of GBV-C/HGV, although proliferative responses appear to be rare.

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