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Human umbilical cord Wharton jelly cells promote extra-pancreatic insulin formation and repair of renal damage in STZ-induced diabetic mice.

Authors
  • Maldonado, Martin1, 2, 3, 4
  • Huang, Tianhua3, 4
  • Yang, Lujun2, 5
  • Xu, Lan3
  • Ma, Lian6, 7, 8, 9
  • 1 Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China. , (China)
  • 2 Translational Medical Center, Second Affiliated Hospital of Shantou University Medical College, 22 Xinling road, Shantou, Guangdong, 515041, People's Republic of China. , (China)
  • 3 Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Research Center for Reproductive Medicine, Shantou University Medical College, Shantou, 515041, People's Republic of China. , (China)
  • 4 Reproductive Medicine & Genetics, Chengdu Jinjiang Hospital for Maternal & Child Health Care, Chengdu, 610066, China. , (China)
  • 5 Department of Burns and Plastic Surgery, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China. , (China)
  • 6 Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China. [email protected] , (China)
  • 7 Translational Medical Center, Second Affiliated Hospital of Shantou University Medical College, 22 Xinling road, Shantou, Guangdong, 515041, People's Republic of China. [email protected] , (China)
  • 8 Department of Pediatrics, Maternal and Child Health Care Hospital of Shenzhen University, 518052, Shenzhen, Guangdong, People's Republic of China. [email protected] , (China)
  • 9 Department of Pediatrics, Maternal and Child Health Care Hospital of Pingshan District, 518122, Shenzhen, Guangdong, People's Republic of China. [email protected] , (China)
Type
Published Article
Journal
Cell communication and signaling : CCS
Publication Date
Oct 17, 2017
Volume
15
Issue
1
Pages
43–43
Identifiers
DOI: 10.1186/s12964-017-0199-5
PMID: 29041943
Source
Medline
Keywords
License
Unknown

Abstract

We confirmed the potential of IP administration of hUCWJCs and the capability of these cells to migrate to damaged tissues and promote insulin secretion from non-pancreatic local cells and to improve renal damage. These findings confer unique therapeutic properties to hUCWJCs, suggesting a promising future in the treatment of diabetes mellitus.

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