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Human tissues as source of colony-stimulating factor in human bone marrow cultures.

Authors
  • Knudtzon, S
  • Hertz, W
Type
Published Article
Journal
Scandinavian journal of haematology
Publication Date
Nov 01, 1977
Volume
19
Issue
5
Pages
482–486
Identifiers
PMID: 304241
Source
Medline
License
Unknown

Abstract

Human bone marrow cells were cultured by the agar method using feeder layers containing human tissue fragments of various origin. Colony stimulating factor (CSF) was shown to be released from all tissues tested (adipose tissue, skeletal muscle, peritoneum and vascular wall), and primary cultures of human fibroblasts could also stimulate colony growth. Colony growth of murine bone marrow cells was also stimulated by all feeder layers. Thus, the study demonstrates that monocytes and macrophages might not be the only source of CSF of possible importance for human granulopoiesis in vivo.

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