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Human T-Cell Lymphotrophic Virus Type-I tax Gene Induces Secretion of Human Macrophage Inflammatory Protein-1α

Authors
  • Sharma, Venkatanarayanan
  • May, Cynthia C
Type
Published Article
Journal
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Publication Date
Jan 01, 1999
Volume
262
Issue
2
Pages
429–432
Identifiers
DOI: 10.1006/bbrc.1999.1242
Source
Elsevier
Keywords
License
Unknown

Abstract

Human T-cell lymphotropic virus I (HTLV-I) encodes for a 40-kDa protein, Tax, which is important for the immortalization of T cells. Tax has been shown to transactivate several cellular genes. In this study, we show that MIP-1α is selectively expressed and secreted in the tax transfected Jurkat cell line upon mitogen stimulation. Expression of MIP-1α-R mRNA in these cells suggests an autocrine role for this chemokine in HTLV-I infected T-cells. Induced MIP-1α expression and secretion in PMA/PHA stimulated tax transfected cells correlate with the noninduction of MNP-1 transcription factor, which is intimately involved in downmodulating the MIP-1α gene.

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