Affordable Access

Human severe combined immune deficiency and DNA repair.

Authors
Type
Published Article
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
Publication Date
Volume
25
Issue
11
Pages
1061–1070
Identifiers
PMID: 14579247
Source
Medline
License
Unknown

Abstract

Human severe combined immune deficiency (SCID) is the most serious inherited immunological deficit. Recent work has revealed defects in the predominant pathway for double-strand break repair called nonhomologous DNA end joining, or NHEJ. Progress in the biochemistry and genetics of NHEJ and of human SCID has proven to be synergistic between these two fields in a manner that covers the range from biochemical etiology to considerations about possible gene therapy for the B- SCID patients.

Statistics

Seen <100 times