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Human Rad52 protein promotes single-strand DNA annealing followed by branch migration.

Authors
  • Reddy, G
  • Golub, E I
  • Radding, C M
Type
Published Article
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Publisher
Elsevier
Publication Date
Jun 09, 1997
Volume
377
Issue
1
Pages
53–59
Identifiers
PMID: 9219578
Source
Medline
License
Unknown

Abstract

In the yeast, Saccharomyces cerevisiae, the Rad52 gene is important for both mitotic and meiotic recombination. Homologs of the Rad52 gene have been identified in several eukaryotic organisms, ranging from yeast to man. As reported here, human Rad52 protein binds to both single- and double-stranded DNA; and acting on a pair of single-stranded and partially duplex substrates it promotes annealing of complementary strands of DNA, which is followed by branch migration.

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