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Human prothrombin activation.

Authors
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Volume
162
Issue
3849
Pages
127–129
Identifiers
PMID: 4970764
Source
Medline

Abstract

Antiserums to human prothrontbin contain antibodies directed against at least two different antigenic sites. During blood coagulation, prothrombin is cleaved into two major antigenically distinct fragments-thrombin and a "pro" fragment. The latter is present in normal seruim, whereas thrombin loses its immunologic reactivity, presumably because of its combination with the natural thrombin inhibitors in blood.

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