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Human prothrombin activation.

Authors
  • Shapiro, S S
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Oct 04, 1968
Volume
162
Issue
3849
Pages
127–129
Identifiers
PMID: 4970764
Source
Medline
License
Unknown

Abstract

Antiserums to human prothrontbin contain antibodies directed against at least two different antigenic sites. During blood coagulation, prothrombin is cleaved into two major antigenically distinct fragments-thrombin and a "pro" fragment. The latter is present in normal seruim, whereas thrombin loses its immunologic reactivity, presumably because of its combination with the natural thrombin inhibitors in blood.

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