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Human platelet interactions with surfaces of type I collagen, chondroitin-4-sulphate, and chondroitin-6-sulphate in vitro.

Authors
  • Umemura, Y1
  • Huskey, R A
  • Anderson, J M
  • 1 Department of Macromolecular Science, Case Western Reserve University, Cleveland, OH 44106.
Type
Published Article
Journal
Biomaterials
Publisher
Elsevier
Publication Date
Mar 01, 1988
Volume
9
Issue
2
Pages
133–137
Identifiers
PMID: 3130901
Source
Medline
License
Unknown

Abstract

In vitro human platelet interactions with surfaces of type I collagen, chondroitin-6-sulphate (CH-6-S), chondroitin-4-sulphate (CH-4-S), a CH-6-S/collagen layer, and a collagen-CH-6-S complex were investigated. Polystyrene and silanized glass served as controls. Platelet counts, platelet factor 4 released, and platelet aggregating ability for the different surfaces were compared with controls. Platelet count and platelet factor 4 release data showed that there were no differences between surfaces of CH-6-S, CH-4-S and the controls. However, significant differences in platelet counts and platelet factor 4 released were found when collagen, the CH-6-S/collagen layer, and the collagen-CH-6-S complex were compared with controls. The pure type I collagen surface had the greatest influence on platelet activation. The collagen-CH-6-S complex had a greater effect that the CH-6-S/collagen layer on platelet activation. It appears that chondroitin-6-sulphate can modify the platelet activity of type I collagen.

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