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Human pegivirus 2 exhibits minimal geographic and temporal genetic diversity.

Authors
  • Forberg, Kenn1
  • Rodgers, Mary A1
  • Dawson, George J1
  • Sauleda, Silvia2
  • Olivo, Ana1
  • Vallari, Ana1
  • Bes, Marta2
  • Piron, Maria2
  • Cloherty, Gavin A1
  • Berg, Michael G3
  • 1 Infectious Diseases Research, Abbott Diagnostics, Abbott Park, IL, USA.
  • 2 Transfusion Safety Laboratory, Banc de Sang i Teixits, Servei Català de la Salut, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain. , (Spain)
  • 3 Infectious Diseases Research, Abbott Diagnostics, Abbott Park, IL, USA. Electronic address: [email protected]
Type
Published Article
Journal
Virology
Publisher
Elsevier
Publication Date
Jan 02, 2020
Volume
539
Pages
69–79
Identifiers
DOI: 10.1016/j.virol.2019.10.012
PMID: 31689572
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We applied an NGS based target capture approach to amplify HPgV-2 sequences from metagenomic libraries and enable full genome characterization. Despite expanded geographical sampling, sequence variability remains low, with diversity concentrated in approximately 3.3% of all amino acids. Serial samples from one HPgV-2 positive individual co-infected with comparable titers of HIV, HCV, and GBV-C showed that HPgV-2 remains highly stable over several weeks compared to other RNA viruses, despite a similarly error-prone polymerase. The consistent epidemiological association with and structural similarities to HCV, and the weak positive correlation of HCV and HPgV-2 titers shown here, suggests it may benefit from co-infection. While minimal selective pressure on HPgV-2 to evolve could suggest fitness, the rarity of HPgV-2 and the tight phylogenetic clustering of global strains likely indicates origination from a common source and a virus that is ill-suited to its host. Sporadic infections may explain the limited genetic diversity observed worldwide. Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

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