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Human papillomavirus type 18 is associated with less apoptosis in fibroblast tumours than human papillomavirus type 16.

Authors
Type
Published Article
Journal
British journal of cancer
Publication Date
Volume
72
Issue
3
Pages
646–649
Identifiers
PMID: 7669576
Source
Medline
License
Unknown

Abstract

In human cervical neoplasia human papillomavirus (HPV) type 18 has a higher cancer/cervical intraepithelial neoplasia (CIN) prevalence ratio than HPV 16. Fibrosarcomas derived from rat fibroblasts transfected with HPV 16 or 18 genomes showed increased apoptosis compared with controls. However, HPV 18 was associated with significantly less apoptosis than HPV 16, affording one possible explanation for the more rapidly progressive cervical neoplasia associated with HPV 18.

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