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Human papillomavirus infection among Egyptian females with cervical carcinoma: relationship to spontaneous apoptosis and TNF-alpha.

Authors
  • Ahmed, M I
  • Salahy, E E
  • Fayed, S T
  • El-Hefnawy, N G
  • Khalifa, A
Type
Published Article
Journal
Clinical Biochemistry
Publisher
Elsevier
Publication Date
Sep 01, 2001
Volume
34
Issue
6
Pages
491–498
Identifiers
PMID: 11676979
Source
Medline
License
Unknown

Abstract

HPV infection, high levels of TNF-alpha and spontaneous apoptosis were strongly associated with malignant phenotype of cervical tissues. Rate of spontaneous apoptosis was higher in AC compared to SCC. On the other hand, HPV negativity was correlated with AI. Moreover, TNF-alpha and apoptotic cell death were correlated to each other as well as to tumor progression. No correlation was detected between TNF-alpha and HPV-16 infection.

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