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Human papillomavirus (HPV) subtypes and their relationships with cervical smear results in cervical cancer screening: a community-based study from the central Anatolia region of Turkey

Authors
  • Findik, Siddika1
  • Findik, Serkan2
  • Abuoğlu, Seyfettin2
  • Cihan, Fatma Goksin3
  • Ilter, Huseyin4
  • Iyisoy, Mehmet Sinan5
  • 1 Department of Pathology, Necmettin Erbakan University Medical School, Konya, Turkey
  • 2 Ministry of Health, Public Health Unit, Konya, Turkey
  • 3 Department of Family Medicine, Necmettin Erbakan University Medical School, Konya, Turkey
  • 4 Ministry of Health, Public Health Institute, Ankara, Turkey
  • 5 MSc, Medical Education and Informatics, Necmettin Erbakan University Medical School, Konya, Turkey
Type
Published Article
Journal
International journal of clinical and experimental pathology
Publication Date
Apr 01, 2019
Volume
12
Issue
4
Pages
1391–1398
Identifiers
PMID: 31933954
PMCID: PMC6947064
Source
PubMed Central
Keywords
License
Unknown

Abstract

Objective: Cervical cancer can be diagnosed early by cancer screening programs. The aim of this study was to evaluate the cervical smear test results of healthy women. Methods: We enrolled 94,848 healthy women from 30-65 years of age in whom both HPV typing and a cervical smear test was performed between 2014 and 2017. Results: HPV was detected in 3001 women (3.16%). The mean age was 42 ± 8.94 years old. Positive HPV types were HPV16; HPV16 and multiple infection; HPV31; HPV51; HPV39; HPV52; HPV56; HPV18; HPV68; HPV35; HPV18 and multiple infection; HPV58; HPV45; HPV59; HPV16, HPV18 and multiple infection; HPV16 and 18; and HPV33, in descending order. Cytology results were normal in 63.61%. We also identified atypical squamous cells of undetermined significance in 6.60%, atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion in 0.73%, low-grade squamous intraepithelial lesion in 10%, high-grade squamous intraepithelial lesion and atypical glandular cells in 0.53%, and adenocarcinoma in situ in 0.03%. In terms of HPV subtypes, abnormal smear results were divided into an HPV16, HPV18, and multiple infection group (25%), an HPV35 group (23.61%), an HPV 16 and multiple infection group (22%), and an HPV16-only group (21.85%). Most cases of HPV (39.02%) and abnormal cytology (43.04%) were detected between the ages of 30 and 40. Conclusions: This study is remarkable because it is a community-based study and includes a large population of healthy women to detect HPV prevalence, its subtype, and abnormal smear results.

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