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Human monocyte-endothelial cell interaction induces synthesis of granulocyte-macrophage colony-stimulating factor.

Authors
  • Takahashi, M
  • Kitagawa, S
  • Masuyama, J I
  • Ikeda, U
  • Kasahara, T
  • Takahashi, Y I
  • Furukawa, Y
  • Kano, S
  • Shimada, K
Type
Published Article
Journal
Circulation
Publication Date
Mar 15, 1996
Volume
93
Issue
6
Pages
1185–1193
Identifiers
PMID: 8653840
Source
Medline
License
Unknown

Abstract

The present results indicate that GM-CSF is produced by direct interaction between monocytes and ECs and suggest that GM-CSF produced locally by monocyte-EC adhesive interaction plays an important role in the pathogenesis of atherosclerosis and inflammation by modulating monocyte/macrophage functions in vivo.

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