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The human microbiome and its link in prostate cancer risk and pathogenesis

Authors
  • Katongole, Paul1, 1
  • Sande, Obondo J.1
  • Joloba, Moses1
  • Reynolds, Steven J.2
  • Niyonzima, Nixon3
  • 1 College of Health Sciences Makerere University, Kampala, Uganda , Kampala (Uganda)
  • 2 National Institutes of Health, Bethesda, MD, USA , Bethesda (United States)
  • 3 Uganda Cancer Institute, Kampala, Uganda , Kampala (Uganda)
Type
Published Article
Journal
Infectious Agents and Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Aug 31, 2020
Volume
15
Issue
1
Identifiers
DOI: 10.1186/s13027-020-00319-2
Source
Springer Nature
Keywords
License
Green

Abstract

There is growing evidence of the microbiome’s role in human health and disease since the human microbiome project. The microbiome plays a vital role in influencing cancer risk and pathogenesis. Several studies indicate microbial pathogens to account for over 15–20% of all cancers. Furthermore, the interaction of the microbiota, especially the gut microbiota in influencing response to chemotherapy, immunotherapy, and radiotherapy remains an area of active research. Certain microbial species have been linked to the improved clinical outcome when on different cancer therapies. The recent discovery of the urinary microbiome has enabled the study to understand its connection to genitourinary malignancies, especially prostate cancer. Prostate cancer is the second most common cancer in males worldwide. Therefore research into understanding the factors and mechanisms associated with prostate cancer etiology, pathogenesis, and disease progression is of utmost importance. In this review, we explore the current literature concerning the link between the gut and urinary microbiome and prostate cancer risk and pathogenesis.

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