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Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adults.

Authors
  • Williams, John V
  • Crowe, James E Jr
  • Enriquez, Rachel
  • Minton, Patricia
  • Peebles, R Stokes Jr
  • Hamilton, Robert G
  • Higgins, Stanley
  • Griffin, Marie
  • Hartert, Tina V
Type
Published Article
Journal
The Journal of infectious diseases
Publication Date
Oct 01, 2005
Volume
192
Issue
7
Pages
1149–1153
Identifiers
PMID: 16136455
Source
Medline
License
Unknown

Abstract

We determined the prevalence of human metapneumovirus (hMPV) infection in adults with asthma who were prospectively enrolled after hospitalization for an acute asthma exacerbation. Nasal wash specimens collected at admission and 3 months after discharge were tested for hMPV by real-time reverse-transcription polymerase chain reaction assays. hMPV was detected in 7 (6.9%) of 101 subjects at hospitalization and in 1 (1.3%) of 75 subjects at follow-up (odds ratio, 7 [95% confidence interval, 0.9-312]; P=.03). None of the patients with hMPV infection at hospitalization tested positive at follow-up, strongly suggesting that hMPV plays a direct etiologic role in acute asthma exacerbations.

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