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Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel K V6.4 Subunit

Authors
  • Lee, Michael C.1
  • Nahorski, Michael S.2
  • Hockley, James R.F.3
  • Lu, Van B.4
  • Ison, Gillian1
  • Pattison, Luke A.3
  • Callejo, Gerard3
  • Stouffer, Kaitlin2
  • Fletcher, Emily2
  • Brown, Christopher5
  • Drissi, Ichrak1
  • Wheeler, Daniel1
  • Ernfors, Patrik6
  • Menon, David1
  • Reimann, Frank4
  • Smith, Ewan St. John3
  • Woods, C. Geoffrey2
  • 1 University Division of Anaesthesia, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK
  • 2 Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK
  • 3 Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, UK
  • 4 Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK
  • 5 Department of Psychological Sciences, Institute of Psychology, Health and Society, University of Liverpool, Liverpool L69 7ZA, UK
  • 6 Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Jul 21, 2020
Volume
32
Issue
3
Identifiers
DOI: 10.1016/j.celrep.2020.107941
PMID: 32697988
PMCID: PMC7383234
Source
PubMed Central
Keywords
License
Unknown

Abstract

Lee et al. find that the KV6.4 variant KV6.4Met-419 is highly prevalent in women requiring no analgesia in childbirth and that KV6.4Met-419 is retained in the cytoplasm, preventing it from modifying KV2.1 channel activity, which results in hypoexcitable sensory neurons.

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