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Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes

Authors
  • Campbell, Scott A.1
  • Golec, Dominic P.1
  • Hubert, Matt1
  • Johnson, Janyne2
  • Salamon, Nicole1
  • Barr, Amy1
  • MacDonald, Patrick E.1
  • Philippaert, Koenraad1
  • Light, Peter E.1
  • 1 Alberta Diabetes Institute and the Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Canada
  • 2 Alberta Diabetes Institute and the Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Canada
Type
Published Article
Journal
Molecular Metabolism
Publisher
Elsevier BV
Publication Date
May 12, 2020
Volume
39
Identifiers
DOI: 10.1016/j.molmet.2020.101014
PMID: 32413586
PMCID: PMC7260680
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Here we show that glucagon-like peptide-1 (GLP-1) is secreted from a subpopulation of α cells within human islets. • Human islets secrete ∼50-fold more GLP-1 than murine islets and that ∼40% of the total human α cells contain GLP-1. • We observed significantly more GLP-1+ α cells in islets from donors with type 2 diabetes than in islets from donors with no diabetes. • GLP-1+ α cells can also be detected in pancreatic islet sections obtained from living donors undergoing surgery. • GLP-1 receptor signaling may support insulin secretion to a greater extent in type 2 diabetes.

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