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Human hyaluronic acid synthase-1 promotes malignant transformation via epithelial-to-mesenchymal transition, micronucleation and centrosome abnormalities.

Authors
  • Nguyen, Nguyet1
  • Kumar, Awanit1
  • Chacko, Simi1
  • Ouellette, Rodney J1, 2
  • Ghosh, Anirban3, 4
  • 1 Atlantic Cancer Research Institute, 35 Providence Street, Moncton, NB, E1C 8X3, Canada. , (Canada)
  • 2 Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada. , (Canada)
  • 3 Atlantic Cancer Research Institute, 35 Providence Street, Moncton, NB, E1C 8X3, Canada. [email protected] , (Canada)
  • 4 Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada. [email protected] , (Canada)
Type
Published Article
Journal
Cell communication and signaling : CCS
Publication Date
Nov 14, 2017
Volume
15
Issue
1
Pages
48–48
Identifiers
DOI: 10.1186/s12964-017-0204-z
PMID: 29137675
Source
Medline
Keywords
License
Unknown

Abstract

The intracellular HA produced by HAS1 can aggravate genomic instability and intratumor heterogeneity, pointing to a fundamental role of intracellular HA in cancer initiation and progression.

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