Affordable Access

[The human hepatocyte: I. A model for studying metabolism and toxicity of xenobiotics].

Authors
Type
Published Article
Journal
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti
Publication Date
Volume
48
Issue
2
Pages
65–71
Identifiers
PMID: 10376418
Source
Medline

Abstract

Isolated human hepatocytes have become one of the most attractive experimental approaches to the study of the specific metabolic functions of the human liver, interactions between liver cells and infectious agents, and metabolism and pharmacotoxicity of drugs. Particularly the primary cell culture model provides an in vitro system for investigating specific mechanisms in a precisely controlled conditions. In the present paper the legislative and ethical problems concerning availability of human liver samples, techniques developed for isolation, preservation and cultivation of hepatocytes are discussed. In addition, a comparison of human and rat hepatocyte models in the study of the metabolism and cytotoxicity of taxol is reviewed.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments