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Human hepatocellular carcinomas with "Stemness"-related marker expression: keratin 19 expression and a poor prognosis.

Authors
  • Kim, Haeryoung
  • Choi, Gi Hong
  • Na, Deuk Chae
  • Ahn, Ei Young
  • Kim, Gwang Il
  • Lee, Jae Eun
  • Cho, Jai Young
  • Yoo, Jeong Eun
  • Choi, Jin Sub
  • Park, Young Nyun
Type
Published Article
Journal
Hepatology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Nov 01, 2011
Volume
54
Issue
5
Pages
1707–1717
Identifiers
DOI: 10.1002/hep.24559
PMID: 22045674
Source
Medline
License
Unknown

Abstract

K19 was well correlated with clinicopathologic features of tumor aggressiveness, compared to other stemness-related proteins. K19-positive HCCs showed significantly increased EMT-related protein and mRNA expression, suggesting that they may acquire more invasive characteristics, compared to K19-negative HCCs through the up-regulation of EMT-associated genes.

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