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Human endometriosis is associated with plasma cells and overexpression of B lymphocyte stimulator.

Authors
  • Hever, Aniko
  • Roth, Richard B
  • Hevezi, Peter
  • Marin, Maria E
  • Acosta, Jose A
  • Acosta, Hector
  • Rojas, Jose
  • Herrera, Rosa
  • Grigoriadis, Dimitri
  • White, Evan
  • Conlon, Paul J
  • Maki, Richard A
  • Zlotnik, Albert
Type
Published Article
Journal
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Publication Date
Jul 23, 2007
Volume
104
Issue
30
Pages
12451–12456
Identifiers
PMID: 17640886
Source
Medline
License
Unknown

Abstract

Endometriosis affects 10-20% of women of reproductive age and is associated with pelvic pain and infertility, and its pathogenesis is not well understood. We used genomewide transcriptional profiling to characterize endometriosis and found that it exhibits a gene expression signature consistent with an underlying autoimmune mechanism. Endometriosis lesions are characterized by the presence of abundant plasma cells, many of which produce IgM, and macrophages that produce BLyS/BAFF/TNFSF13B, a member of the TNF superfamily implicated in other autoimmune diseases. B lymphocyte stimulator (BLyS) protein was found elevated in the serum of endometriosis patients. These observations suggest a model for the pathology of endometriosis where BLyS-responsive plasma cells interact with retrograde menstrual tissues to give rise to endometriosis lesions.

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