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Human CNS cultures exposed to HIV-1 gp120 reproduce dendritic injuries of HIV-1-associated dementia

Authors
  • Iskander, Sam1
  • Walsh, Kimberley A1
  • Hammond, Robert R1, 2
  • 1 University of Western Ontario, Department of Pathology, London Health Sciences Centre, London, ON, Canada , London
  • 2 University of Western Ontario, Department of Clinical Neurological Sciences, London Health Sciences Centre, London, ON, Canada , London
Type
Published Article
Journal
Journal of Neuroinflammation
Publisher
Springer (Biomed Central Ltd.)
Publication Date
May 27, 2004
Volume
1
Issue
1
Identifiers
DOI: 10.1186/1742-2094-1-7
Source
Springer Nature
Keywords
License
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Abstract

HIV-1-associated dementia remains a common subacute to chronic central nervous system degeneration in adult and pediatric HIV-1 infected populations. A number of viral and host factors have been implicated including the HIV-1 120 kDa envelope glycoprotein (gp120). In human post-mortem studies using confocal scanning laser microscopy for microtubule-associated protein 2 and synaptophysin, neuronal dendritic pathology correlated with dementia. In the present study, primary human CNS cultures exposed to HIV-1 gp120 at 4 weeks in vitro suffered gliosis and dendritic damage analogous to that described in association with HIV-1-associated dementia.

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