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Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Authors
  • Ndila, Carolyne M
  • Uyoga, Sophie
  • Macharia, Alexander W
  • Nyutu, Gideon
  • Peshu, Norbert
  • Ojal, John
  • Shebe, Mohammed
  • Awuondo, Kennedy O
  • Mturi, Neema
  • Tsofa, Benjamin
  • Sepúlveda, Nuno
  • Clark, Taane G
  • Band, Gavin
  • Clarke, Geraldine
  • Rowlands, Kate
  • Hubbart, Christina
  • Jeffreys, Anna
  • Kariuki, Silvia
  • Marsh, Kevin
  • Mackinnon, Margaret
  • And 5 more
Publication Date
Aug 01, 2018
Identifiers
DOI: 10.1016/S2352-3026(18)30107-8
PMID: 30033078
OAI: oai:HAL:pasteur-02084676v1
Source
HAL-SHS
Keywords
Language
English
License
Unknown
External links

Abstract

Background Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms-many related to the structure or function of red blood cells-and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress.

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