Human breast carcinoma: heterotransplantation to newborn rats.
- Published Article
- Publication Date
Mar 01, 1976
Cultured cells from a human breast carcinoma (HBC) were injected subcutaneously in newborn cortisone-treated Sprague-Dawley rats (CNBR). Tumors of predominantly epithelial nature appeared in all within 30 days, and wipespread metastases occured often. Cells cultured from these tumors rapidly produced similar tumors in CNBR. Rat-to-rat passage by implanting fragments of tumor tissue was 100% successful in CNBR. The in vivo model described is simple and inexpensive.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/1016945