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Human breast carcinoma: heterotransplantation to newborn rats.

Authors
  • Benjamin, I
  • Pinkerton, H
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Mar 01, 1976
Volume
1
Issue
4
Pages
203–206
Identifiers
PMID: 1016945
Source
Medline
License
Unknown

Abstract

Cultured cells from a human breast carcinoma (HBC) were injected subcutaneously in newborn cortisone-treated Sprague-Dawley rats (CNBR). Tumors of predominantly epithelial nature appeared in all within 30 days, and wipespread metastases occured often. Cells cultured from these tumors rapidly produced similar tumors in CNBR. Rat-to-rat passage by implanting fragments of tumor tissue was 100% successful in CNBR. The in vivo model described is simple and inexpensive.

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