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Human breast carcinoma cells express type II IL-4 receptors and are sensitive to antitumor activity of a chimeric IL-4-Pseudomonas exotoxin fusion protein in vitro and in vivo.

Authors
  • Leland, P
  • Taguchi, J
  • Husain, S R
  • Kreitman, R J
  • Pastan, I
  • Puri, R K
Type
Published Article
Journal
Molecular medicine (Cambridge, Mass.)
Publication Date
Mar 01, 2000
Volume
6
Issue
3
Pages
165–178
Identifiers
PMID: 10965493
Source
Medline
License
Unknown

Abstract

These results suggest that IL-4(38-37)-PE38KDEL may be a useful agent for targeting of IL-4 receptor positive human breast carcinomas and further studies should be performed to explore fully its potential.

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