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Human biomonitoring of neonicotinoid exposures: case studies after the use of a spray-agent to ornamental plants and a topical medication to pets

Authors
  • Wrobel, Sonja A.1
  • Koslitz, Stephan1
  • Bury, Daniel1
  • Hayen, Heiko2
  • Koch, Holger M.1
  • Brüning, Thomas1
  • Käfferlein, Heiko U.1
  • 1 Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Ruhr University Bochum (IPA), Bochum , (Germany)
  • 2 Institute of Inorganic and Analytical Chemistry, University of Münster, Münster , (Germany)
Type
Published Article
Journal
Frontiers in Public Health
Publisher
Frontiers Media SA
Publication Date
Jan 23, 2024
Volume
11
Identifiers
DOI: 10.3389/fpubh.2023.1321138
Source
Frontiers
Keywords
Disciplines
  • Public Health
  • Brief Research Report
License
Green

Abstract

Acetamiprid (ACE) and imidacloprid (IMI) are insecticides of global importance and are used as spray and watering agents for ornamental plants to control biting and sucking insects or as topical medications on pets to remove and control fleas. Human biomonitoring data on ACE and IMI exposures when applying these products are limited. We investigated exposures to ACE and IMI in male volunteers after the domestic application of either an ACE-containing agent or an IMI-containing spot-on medication. Complete and consecutive urine samples were collected for up to 56 h after application. Urine samples were analyzed for ACE, IMI, and their respective metabolites (N-desmethyl-ACE, IMI-olefin, and sum of 4−/5-hydroxy-IMI) by liquid chromatography–tandem mass spectrometry. Fairly uniform concentrations of N-desmethyl-ACE could be observed before and after orchid treatment, so that an ACE exposure associated with orchid treatment can most likely be excluded. In contrast, after the application of the IMI-containing medication, elevated concentrations of IMI, 4−/5-hydroxy-IMI, and IMI-olefin were quantified in urine samples post-20 h with maximum concentrations of 3.1, 14.9, and 8.0 μg/g creatinine, respectively, well above general background levels. Nevertheless, the IMI intake (10.6 μg/kg bw), calculated from the excreted amounts, was around five times below the current European acceptable daily intake. Based on the case results here, household exposures to ACE and IMI after spray treatment of ornamental plants and anti-flea treatment of dogs can be regarded as low and safe. However, people regularly applying neonicotinoid-containing formulations, such as professional gardeners and employees in animal shelters, should be studied in more detail.

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