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Human B cells express a CD45 isoform that is similar to murine B220 and is downregulated with acquisition of the memory B-cell marker CD27.

Authors
  • Bleesing, Jack J H
  • Fleisher, Thomas A
Type
Published Article
Journal
Cytometry. Part B, Clinical cytometry
Publication Date
Jan 01, 2003
Volume
51
Issue
1
Pages
1–8
Identifiers
PMID: 12500291
Source
Medline
License
Unknown

Abstract

The B220 isoform in humans is developmentally regulated in humans, tied to the acquisition of a memory phenotype, and as such can be used as a differentiation-specific CD45 isoform, akin to the use of CD45 isoforms to distinguish between naive and memory T-cell subsets. Patients with immunodeficiency disorders, associated with defective memory B-cell generation and absent or reduced CD27(+) B cells, showed a corresponding lack of B220 downregulation consistent with altered differentiation of B-cell subsets.

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