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Human antigen R: A potential therapeutic target for liver diseases.

Authors
  • Liu, Runping1
  • Wu, Kaiyi2
  • Li, Yajing3
  • Sun, Rong2
  • Li, Xiaojiaoyang4
  • 1 School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Beijing, 100029, China. , (China)
  • 2 The Second Hospital of Shandong University, 247 Bei Yuan Da Jie, Jinan, 250033, China. , (China)
  • 3 School of Life Sciences, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Beijing, 100029, China. , (China)
  • 4 School of Life Sciences, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Beijing, 100029, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Pharmacological Research
Publisher
Elsevier
Publication Date
Feb 08, 2020
Volume
155
Pages
104684–104684
Identifiers
DOI: 10.1016/j.phrs.2020.104684
PMID: 32045667
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Human antigen R (HuR), also known as HuA and embryonic lethal abnormal vision-like 1 (ELAVL1), is a ubiquitously expressed RNA binding protein and functions as an RNA regulator and mediates the expression of various proteins by diverse post-transcriptional mechanisms. HuR has been well characterized in the inflammatory responses and in the development of various cancers. The importance of HuR-mediated roles in cell signaling, inflammation, fibrogenesis and cancer development in the liver has attracted a great deal of attention. However, there is still a substantial gap between the current understanding of the potential roles of HuR in the progression of liver disease and whether HuR can be targeted for the treatment of liver diseases. In this review, we introduce the function and mechanistic characterization of HuR, and then focus on the physiopathological roles of HuR in the development of different liver diseases, including hepatic inflammation, alcoholic liver diseases, non-alcoholic fatty liver diseases, viral hepatitis, liver fibrosis and liver cancers. We also summarize existing approaches targeting HuR function. In conclusion, although characterizing the liver-specific HuR function and demonstrating the multi-level regulative networks of HuR in the liver are still required, emerging evidence supports the notion that HuR represents a potential therapeutic target for the treatment of chronic liver diseases. Copyright © 2020 Elsevier Ltd. All rights reserved.

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