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HTLV-III antibody and T-cell subset ratios in haemophiliacs and their spouses.

Authors
  • McVerry, B A
  • Machin, S J
  • Galloway, M J
  • McCarthy, K
  • Evans, P
  • Barnes, R M
  • Turner, G C
  • Cheingsong-Popov, R
  • Tedder, R S
  • Winter, M
Type
Published Article
Journal
British journal of haematology
Publication Date
Jun 01, 1986
Volume
63
Issue
2
Pages
347–352
Identifiers
PMID: 3013274
Source
Medline
License
Unknown

Abstract

44% of 63 British patients with either haemophilia A or B were HTLV-III antibody positive (HTLV-VIII+). HTLV-III+ was more frequent in high factor VIII concentrate users and 75% of severely affected haemophilia A patients were HTLV-III+. All eight patients who were exposed to factor IX concentrate were HTLV-III-. 17 haemophilia A patients who received only British made factor VIII concentrate (average 12,000 units/year) were HTLV-III-. Two of 63 patients had evidence of a pre-AIDS type symptom complex and both were HTLV-III+. Information from a cohort of 21 Liverpool haemophiliacs suggests that HTLV-III was first introduced into this country in 1981. OKT4/T8 ratios were abnormal in 52% of 21 patients studied but this finding was not confined to either HTLV-III+ or HTLV-III- individuals. The spouses of 14 HTLV-III+ haemophiliacs were all HTLV-III-.

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