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HPLC-assisted automated oligosaccharide synthesis.

Authors
Type
Published Article
Journal
Organic Letters
1523-7052
Publisher
American Chemical Society
Publication Date
Volume
14
Issue
12
Pages
3036–3039
Identifiers
DOI: 10.1021/ol301105y
PMID: 22646669
Source
Medline
License
Unknown

Abstract

A standard HPLC was adapted to polymer supported oligosaccharide synthesis. Solution-based reagents are delivered using a software-controlled solvent delivery system. The reaction progress and completion can be monitored in real time using a standard UV detector. All steps of oligosaccharide assembly including loading, glycosylation, deprotection, and cleavage can be performed using this setup.

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