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HPA axis stress reactivity and hair cortisol concentrations in recently detoxified alcoholics and healthy controls with and without childhood maltreatment.

Authors
  • Muehlhan, Markus1, 2
  • Höcker, Anja3
  • Miller, Robert4
  • Trautmann, Sebastian2
  • Wiedemann, Klaus3
  • Lotzin, Annett3, 5
  • Barnow, Sven6
  • Schäfer, Ingo3, 5
  • 1 Department of Psychology, Faculty of Human Science, Medical School Hamburg, Hamburg, Germany. , (Germany)
  • 2 Institute of Clinical Psychology and Psychotherapy, Faculty of Psychology, School of Science, Technische Universität Dresden, Dresden, Germany. , (Germany)
  • 3 Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. , (Germany)
  • 4 Institute of General Psychology, Biological Psychology and Methods in Psychology, Faculty of Psychology, School of Science, Technische Universität Dresden, Germany. , (Germany)
  • 5 Center for Interdisciplinary Addiction Research, University of Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. , (Germany)
  • 6 Department of Clinical Psychology and Psychotherapy, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany. , (Germany)
Type
Published Article
Journal
Addiction Biology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Jan 01, 2020
Volume
25
Issue
1
Identifiers
DOI: 10.1111/adb.12681
PMID: 30307081
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Childhood maltreatment (CM) is a strong risk factor for alcohol dependence (AD) and is associated with a more severe course of the disease. Alterations of the hypothalamic-pituitary-adrenal (HPA) axis may play an important role in this relationship. The aim of the present study was to systematically investigate potential alterations in HPA functioning associated with AD diagnosis and CM. Four study groups were recruited: AD patients with (n = 29; 10♀) and without (n = 33; 8♀) CM and healthy controls with (n = 30; 20♀) and without (n = 38; 15♀) CM. Cumulative cortisol secretion was measured by hair cortisol concentration (HCC). To measure HPA axis response to the Trier social stress test (TSST), saliva and blood samples were analysed for adrenocorticotropic hormone (ACTH) and cortisol. In the AD groups, the period of hair growth covered acute alcohol consumption and withdrawal. The TSST was scheduled after completion of withdrawal. Irrespective of CM, higher HCCs and reduced ACTH and cortisol levels before and after TSST were observed in AD patients. The analyses did not reveal any differences between AD patients with and without CM. Healthy controls with CM had lower plasma cortisol levels compared with those without CM. The results suggest that AD is strongly related to HPA axis functioning, which may superimpose possible differences between AD patients with and without CM. Future studies should investigate whether biologically different subtypes of AD with and without CM can be identified in earlier stages or before the development of AD. © 2018 Society for the Study of Addiction.

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