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The HPA-axis and immune function in burnout.

Authors
  • Mommersteeg, Paula M C1
  • Heijnen, Cobi J
  • Kavelaars, Annemieke
  • van Doornen, Lorenz J P
  • 1 Laboratory for Psychoneuroimmunology, Division of Perinatology and Gynaecology, University Medical Center Utrecht, 3508 AB, Utrecht, The Netherlands. [email protected] , (Netherlands)
Type
Published Article
Journal
Progress in brain research
Publication Date
Jan 01, 2008
Volume
167
Pages
281–285
Identifiers
PMID: 18037026
Source
Medline
License
Unknown

Abstract

Burnout results from chronic work stress. Its complaints may be related to HPA-axis disturbances or changes in immune function. In our studies the salivary cortisol awakening response, day-curve, and the suppressed level after dexamethasone intake were not different in a burned-out group compared to a control group. Nor was there a change in cortisol after a treatment period. Higher levels of DHEAS and the monocyte released anti-inflammatory cytokine IL-10 were observed, however T-cell stimulated and dexamethasone inhibited cytokine release were not affected. The increased IL-10 level may be related to an increased sensitivity for infections.

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