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How stem cells remember their past.

Authors
  • Royall, Lars N1
  • Jessberger, Sebastian2
  • 1 Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057, Zurich, Switzerland. , (Switzerland)
  • 2 Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057, Zurich, Switzerland. Electronic address: [email protected] , (Switzerland)
Type
Published Article
Journal
Current opinion in cell biology
Publication Date
Jan 08, 2021
Volume
69
Pages
17–22
Identifiers
DOI: 10.1016/j.ceb.2020.12.008
PMID: 33429112
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Somatic stem cells are required for tissue development, homeostasis, and repair. Recent data suggested that previous biographical experiences of individual stem cells influence their behavior in the context of tissue formation and govern stem cell responses to external stimuli. Here we provide a concise review how a cell's biography, for example, previous rounds of cell divisions or the age-dependent accumulation of cellular damage, is remembered in stem cells and how previous experiences affect the segregation of cellular components, thus guiding cellular behavior in vertebrate stem cells. Further, we suggest future directions of research that may help to unravel the molecular underpinnings of how past experiences guide future cellular behavior. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

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