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How is muscle phenotype controlled by nerve activity?

Authors
  • Schiaffino, S
  • Murgia, M
  • Serrano, A L
  • Calabria, E
  • Pallafacchina, G
Type
Published Article
Journal
Italian journal of neurological sciences
Publication Date
Dec 01, 1999
Volume
20
Issue
6
Pages
409–412
Identifiers
PMID: 10937861
Source
Medline
License
Unknown

Abstract

Motor neurons are known to affect muscle growth and fiber type profile (fast/slow, oxidative/glycolytic) by regulating muscle gene expression. However, the mechanism by which the information contained in specific action potential patterns is decoded by the transcriptional machinery of muscle fiber nuclei remains to be established. This is a basic issue in nerve/muscle biology, which has major implications in neurology, sport medicine and aging. We describe here a general strategy aimed at identifying the signal transduction pathways mediating the effects of nerve activity. This approach is based on the overexpression of constitutively active or dominant negative transduction factors in regenerating skeletal muscle.

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